INSTITUTE OF ENGINEERING IN MEDICINE

CMILS Kickoff Symposium Followup

Need to image synaptic receptors at molecular resolution? Roger Tsien, Ph.D. (Professor of Pharmacology and Chemistry & Biochemistry and Howard Hughes Medical Institute, UCSD) has developed a miniSOG fusion protein that produces singlet oxygen and high resolution precipitates visible by electron microscopy. Want to image CD8 T cells interacting with beta cells in pancreatic islets of diabetic mice? Talk to Matthias von Herrath, M.D. (Director of the Center for Type 1 Diabetes Research, Professor, LIAI) who has developed multiphoton microscopy for pancreatic live cell imaging. Is your unruly c. elegans wiggling too much? Call Alex Groisman, Ph.D. (Associate Professor of Physics, UCSD) who has constructed collapsible silicone chambers to immobilize the worm long enough to get high quality images. Your organism is too big for this? Tom Liu, Ph.D. (Director of the UCSD Center for Functional MRI) has developed mouse MRI to visualize beating hearts, tumors or the optic nerve. Need to image hematopoietic stem cells in zebrafish? David Traver, Ph.D. (Cell and Developmental Biology, Department of Cellular and Molecular Medicine, UCSD) may be able to help you with colorful cell-specific probes that allow long-term live imaging. Interested in the role of proteases in septic and circulatory shock? Geert Schmid-Schönbein, Ph.D. (Professor of Bioengineering, UCSD) specializes in imaging various receptors and their proteolytic cleavage on endothelial cells in affected organs. Wondering how blockade of a perforating artery affects the cerebral cortex and produces cognitive impairment? David Kleinfeld, Ph.D. (Professor of Physics and Neurobiology, UCSD) has a model to study just that, in living anesthetized rats. The lesions can spread, and they become unable to cross a gap in a water maze. Your specialty is tumor biology? Bob Mattrey, M.D. (Professor of Radiology UCSD) images the angiogenic ring around mammary tumors and hepatocallular carcinomas using contrast-enhanced ultrasound. And Joshua Rychak, Ph.D., Chief Scientific Officer of Targeson produces the appropriate contrast agents, targeted to the vascular endothelial cell growth factor-2 (VEGFR2), among others. Ultrasound resolution (around 100 μm) is not good enough for your scientific questions? You may want to call Adam Engler, Ph.D. (Bioengineering, UCSD) who uses scanning probe microscopy, a variation of atomic force microscopy, to not only image cells at super-high resolution, but also measures their viscoelastic properties. Wondering what the footprint of your favorite cell looks like under flow? Talk to Klaus Ley, M.D. (Head, Division of Inflammation Biology, LIAI) who has a 2-color total internal reflection microscopy system that images just that.

2011 Wireless Health Conference a Huge Success

The second annual 2011 Wireless Health Conference, co-sponsored by the Institute of Engineering in Medicine, took place October 10–11th in La Jolla, California. The attendees of the conference, with expertise that span from academia to government, gathered for two days for industry tutorials and peer-reviewed research that included the presentation of papers and technical demonstrations. Dr. Paul Jacobs, the founder and CEO of Qualcomm, emphasized in his keynote presentation his company’s commitment to advancing wireless healthcare. Other industry presenters included Analog Devices, Texas Instruments, Medtronic, and the Ford motor company. The Ford company also demonstrated their first public viewing of their in-car Health and Wellness solution.

Advanced Imaging Equipment and Services Available from the La Jolla Institute for Allergy & Immunology

The La Jolla Institute for Allergy & Immunology has several cutting-edge technologies and world-class services available for researchers. MRI machines and confocal microscopes are available including optional assistance for use. The following Excel documents outline the available items and rates.

CMILS_Instruments | CMILS_Chargeback_Rate_Schedule

For more information or questions contact Dr. Klaus Ley: klaus@liai.org

The New York Stem Cell Foundation Requests Applications for Innovator Awards for Early Career Investigators

NYSCF is soliciting applications from early career investigators for awards that will cultivate research exploring the therapeutic potential of human stem cells. The main goal of this initiative is to foster truly innovative science with the probability for transforming the field of stem cell research, and advance the understanding and eventual use of stem cells for the treatment of human disease. In addition to providing funding, NYSCF would partner with the investigator to advance translational goals of the research.

The award provides a maximum of $300K per annum for a period of up to five years. The award does not provide additional institutional overhead.

Please see the attached PDFs for more information:

2011 NYSCF Stem Cell Investigator flyer | NYSCFStem Cell Investigator RFA_2011