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Cardiac Biomedical Science and Engineering Center (CBSEC)

Co-directors
Sylvia Evans, Professor of Medicine and Professor of Pharmaceutical Sciences
Kirk Knowlton, Professor of Medicine
Andrew McCulloch, Distinguished Professor of Bioengineering and Adjunct Professor of Medicine

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Computational modeling to improve diagnosis and treatment of heart failure and rhythm disorders.
 

The mission of the Cardiac Biomedical Science and Engineering Center (CBSEC) is to combat heart diseases, which are the leading cause of morbidity and mortality. The CBSEC will bring together scientists and students in the UCSD School of Medicine, the Skaggs School of Pharmacy and Pharmaceutical Sciences, the Jacobs School of Engineering, neighboring institutions in La Jolla institutions, and industry to elucidate the pathogenic mechanisms of cardiac diseases, create innovative technologies for cutting-­‐edge cardiac research, and to develop novel strategies to improve diagnosis, treatment and prevention of heart diseases. The members of this new center have a well-­‐established track record of strong interdisciplinary collaboration in cardiac biomedical science and engineering.

The main research areas to be pursued will be cardiac development, cardiac hypertrophy, heart failure, cardiac ischemia and hypoxia, and cardiac regeneration. A unique feature of the interdisciplinary research and clinical translation to be pursued is the utilization and development of state-­‐of-­‐the-­‐art bioengineering technologies in combination with sophisticated cellular and molecular biological approaches. Bioengineering technologies will include biomechanics, tissue engineering, biomaterials, biomedical imaging, biophotonics, and systems biology and multi-­‐scale modeling. Cellular and molecular biologic approaches will include investigation of cardiac regeneration from cell culture to the intact heart and use of genetically engineered models to study cardiac diseases.

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Optical mapping of electrical activation on the heart surface. Blue: Early. Red: Late.
 

The CBSEC leverages on the strong program on cardiac mechanics in UCSD to investigate the regional mechanics of the cardiac ventricle in relation to heart diseases and tissue remodeling. The interplay between mechanics and electrical activity, which are especially important in heart failure and arrhythmias, will be studied by combining in-­vitro, in-­vivo and in-­silico approaches. The molecular basis of normal and pathological structure/function of the heart will be elucidated by using high-­‐resolution medical imaging and biophotonics, in combination with genetic and molecular approaches to develop novel, molecular models of cardiac disease. The cellular and molecular responses to mechanical forces are studied in normal and failing hearts. Systems biology approach is used to integrate the complex biomedical findings through network construction, computer modeling, hypothesis generation, and experimentation. Computation modeling and analysis are applied to bedside to improve clinical management of heart diseases.

Stem cells and biomaterials have great potential for regenerative medicine therapy to restore, maintain, and/or enhance tissue and organ functions. Particular emphasis will be placed on the role of the microenvironment of the myocardial cells in combination with manipulation of the signaling cues that are important for cardiac regeneration. These approaches include understanding of the chemical and mechanical properties of the cell matrix, in the differentiation of stem cells for use in regenerating injured and diseased cardiovascular tissue.

These interdisciplinary research collaborations will be closely coupled to the training of the next-­‐generation of physicians/scientists, the enhancement of academia-­‐industry interactions, and the translation of research findings to clinical medicine, in collaboration with the Sulpizio Family Cardiovascular Center. The ultimate goals are to benefit the patients suffering from heart diseases and improve the health and wellbeing of all citizens.

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Computational modeling to improve diagnosis and treatment of heart failure and rhythm disorders.

Center Contacts

For more information about this center please contact the principal investigators