Richard Wyatt

Professor

Dr. Richard Wyatt is a Professor of Immunology and Director of Viral Immunology at Scripps Research. He received his B.S. in Biology from Trinity College in 1974, M.S. in Biology from Southern Connecticut State University in 1982, and Ph.D. in Immunology from Tufts University, School of Medicine in 1991.

His research focuses on HIV-1 Envelope Glycoprotein Structure and Immunogenicity. The human immunodeficiency virus type 1 (HIV-1) is the etiologic agent of AIDS causing a huge toll of human malaise and morbidity. Although a substantial arsenal of drugs can treat this devastating disease, a broadly effective vaccine remains the most cost-effective way to halt further spread of this virus in the human population. However, due to the approximately 32 million infected individuals already infected in the human population world-wide, and the incredible diversity of this virus in the individual and the population, such a vaccine has proven difficult to develop. Because most viral vaccines protect against disease by neutralizing antibodies, we study the HIV-1 envelope glycoproteins (Env) as antigens, as immunogens and at the atomic level of structural refinement to gain insight in how to better elicit antibodies directed against these external, variable and heavily glycosylated neutralizing determinants. We make specialized Env variants and analyze their biochemical and biophysical features, use them as probes to isolate new and novel broadly neutralizing antibodies and assess their immunogenicity all as part of the plan to better elicit neutralizing antibodies by rational, structure-guided vaccine design.