The focus of the Evans lab is to define genetic pathways underlying heart development and to apply that understanding to both congenital and adult heart disease. A basic understanding of heart development is key toward understanding congenital heart disease. Building a functioning heart requires specification and interaction of a number of distinct cell lineages. The Evans lab is trying to understand cardiac lineage specification and the cross talk between these lineages required to build the heart. Another focus of the lab is the behavior of cell populations in the heart follow cardiac injury. Mouse and embryonic stem cells are model systems.