The overriding interest of my laboratory is gene therapy. We are continuing our interest in the assembly and in vivo targeting of viral vectors and non-viral nanoparticle vectors. We are applying these gene transfer methods as well as microarray-based transcriptional profiling and proteomic techniques to the study of a neuro-degenerative and developmental CNS disorder. We are also using microarray and proteomic methods to characterize the developmental pathways in human embryonic stem cells that produce classes of neurons, especially dopaminergic neurons. My laboratory is also using transcriptional and proteomic techniques to examine the mechanisms of action of muscle growth factors and anabolic steroids, both in vitro and in vivo. Focus Area: Genetic Disease.